Annual Report 2009

I. Outline of the Noda Institute for Scientific Research

C. S. Escaño, P. R. Juvvadi, F. J. Jin, T. Takahashi, Y. Koyama, S. Yamashita, J. Maruyama, K. Kitamoto: Disruption of the Aopex11-1 gene involved in peroxisome proliferation leads to impaired Woronin body formation in Aspergillus oryzae.
　Reproduced from Eukaryot. Cell, 8: 296-305 (2009) by copyright permission of American Society for Microbiology
Y. Seshime, P. R. Juvvadi, M. Tokuoka, Y. Koyama, K. Kitamoto, Y. Ebizuka, I. Fujii: Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid.
　Reproduced from Bioorg. Med. Chem. Lett., 19: 3288-3292 (2009) by copyright permission of Elsevier Ltd.
T. Takahashi, F. J. Jin, Y. Koyama: Nonhomologous end-joining deficiency allows large chromosomal deletions to be produced by replacement-type recombination in Aspergillus oryzae.
　Reproduced from Fungal Genet. Biol., 46: 815-824 (2009) by copyright permission of Elsevier Inc.

Taketomo FUJIWARA (Shizuoka University): Development of halophilic protein expression system capable of creating a productive enzyme
Masato IKEDA (Shinshu University): Elucidation of genes relevant to microaerobic growth of Corynebacterium glutamicum
Takashi KAWAGUCHI (Osaka Prefecture University): Establishment of marker-recycling method in filamentous fungi and development of an Aspergillus aculeatus multi-auxotrophic host
Fujio KAWAMURA (Rikkyo University): Development of a translation system highly expressing the target gene in B. subtilis
Hiroshi KITAGAKI (Saga University): A research on mitochondria-targeted breeding of a novel brewery yeast

Jiro ARIMA (Tottori University): Molecular evolution of Streptomyces serine peptidase for the synthesis of β-alanyl-histidine
Hiroki HIGASHIBATA (Toyo University): Analysis of tRNA modification system in halophilic archaea
Takashi HIRASAWA (Osaka University): Fundamental researches on increasing applicability of Saccharomyces cerevisiae as the host cells for production of useful metabolites
Hisashi MURAMATSU (Kochi University): Molecular breeding of enzymes catalyzing asymmetric reactions: Aimed to provide a non-natural amino acid chemical library
Akihiro SAITO (Chiba University): Exploration of novel transporter proteins for oligosaccharides using the ATPase (MsiK)
Kaneyoshi YAMAMOTO (Hosei University): Regulation of genes expression on Escherichia coli genome with communications among microbes

Yasuo OHNISHI (The University of Tokyo): Studies on regulation of secondary metabolism and morphogenesis of Streptomyces by DNA microarray analysis