I．Achievement of Research Activities in 2021
Papers
H.Kudo, G.Arakawa, S.Shirai, M.Ogawa, H.Shindo, M.Hosaka and M. Tokuoka
New role of a histone chaperone, HirA: Involvement in kojic acid production associated with culture conditions in Aspergillus oryzae.
J. Biosci. Bioeng. 133: 235-242 (2022)
P.A.de Castro, A.C.Colabardini, M.Moraes, M.A.C.Horta, ,S.L.Knowles, H.A.Raja, N.H.Oberlies, Y. Koyama, M.Ogawa, K.Gomi, J.L.Steenwyk, A.Rokas, R.A.Gonçales, C.Duarte-Oliveira, A.Carvalho, L.N.A.Ries and G.H.Goldman
Regulation of gliotoxin biosynthesis and protection in Aspergillus species.
PLoS Genet. 18 (1): e1009965 (2022)
II.Grant project
NISR provides research grants to researchers in the field of applied biology for the purpose of developing the fermentation and brewing industry, and building a sustainable society.
1) 2021 NISR Research Grant
Teigo ASAI（Tohoku University）
Discovery of cryptic fungal natural products by using genome rearrangement
Shigeki EHIRA（Tokyo Metropolitan University）
Complete conversion of sugars synthesized by photosynthesis into commodity products
Eiji MASAI（Nagaoka University of Technology）
Stereoselective catabolism of β-1 type lignin-derived aromatic isomers in Sphingobium sp. strain SYK-6
Hiromichi MINAMI（Ishikawa Prefectural University）
Fermentation production of plant alkaloids by synthetic biology for drug development
Toshiyuki WAKIMOTO（Hokkaido University）
Synthetic biology of non-ribosomal cyclopeptide
Seiya WATANABE（Ehime University）
Understanding of catalytic mechanism of flavin-containing dehydrogenases and its bioindustrial application
Toshiharu YAKUSHI（Yamaguchi University）
Role of the cell-surface oxidation system on the cell growth in acetic acid bacteria
2) 2021 NISR Young Investigator Research Grant
Ryo IWAMA（The University of Tokyo）
Contribution of membrane lipid unsaturation to temperature-dependent changes of secreted protein in the filamentous fungus Aspergillus oryzae
Daisuke KURITA（Hirosaki University）
Screening of drug candidates that inhibit ArfA-dependent ribosome rescue system
Yoshiya SETO（Meiji University）
Identification of Strigolactone-like molecules from plant pathogens
Mizuki TANAKA（Tokyo University of Agriculture and Technology）
Novel conidiation regulatory mechanism by N-end rule pathway in Aspergillus oryzae
Keiko UECHI（University of the Ryukyus）
Elucidation of molecular weight control system for fungal cell wall polysaccharide Nigeran and establishment of its fermentation production system
3) 2020 NISR Research Grant
Kohsuke HONDA（Osaka University）
Development of a hybrid bio-conversion system consisting of in vivo fermentation and in vitro enzymatic conversion
Yukio KIMATA（Nara Institute of Science and Technology）
Generation of high-lipid producing yeast cells using the endoplasmic reticulum-stress response
Saori KOSONO（The University of Tokyo）
Characterization of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase hybrid complex from Corynebacterium glutamicum
Akira MATSUURA（Chiba University）
Elucidation of the stationary-phase specific amino acid catabolic pathway in budding yeast and its application to cell longevity
Katsuhide MIYAKE（Meijo University）
De novo transcriptome assembly of the midgut glands of the herbivorous land crab Chiromantes haematocheir, and identification of laccase genes involved in lignin degradation
Osamu MIZUTANI（University of the Ryukyus）
Elucidation of the mechanism of excessive heat generation during koji making
Motohiro TANI（Kyushu University）
Construction of a ceramide production system using rescue mechanism against impaired biosynthesis of sphingolipids
4) 2020 NISR Young Investigator Research Grant
Fumihiro ISHIKAWA（Kindai University）
Enzymatic characterization of non-ribosomal peptide synthetases condensation domains using an engineered adenylation domain with an enlarged substrate-binding pocket
Atsushi KOUZUMA（Tokyo University of Pharmacy and Life Sciences）
Electrochemical control of bacterial metabolism and its application to bioproduction
Takuto KUMANO（University of Tsukuba）
Elucidation of a cofactor-metabolizing pathway in bacteria
Kazunori KUME（Hiroshima University）
Study of organelle size control in yeast
Tomohiko MATSUZAWA（National Institute of Advanced Industrial Science and Technology (AIST)）
Construction of an Aspergillus enzyme library for the development of novel materials
5) 2018 NISR Research Grant
Hiroyuki TACHIKAWA（The Unversity of Tokyo）
The role of membrane contact sites during prospore membrane formation in budding yeast